Adhesina P97 de Mycoplasma hyopneumoniae

Papel en la patogenia de la enfermedad e implicancias en el desarrollo de nuevas vacunas y técnicas diagnósticas

  • Pablo Jesus Tamiozzo Facultad de Agronomía y Veterinaria, Universidad Nacional de Río Cuarto, Córdoba, Argentina.
  • Agustina Cots Facultad de Agronomía y Veterinaria, Universidad Nacional de Río Cuarto, Córdoba, Argentina.

Resumen

Mycoplasma hyopneumoniae es el agente causal de la neumonía enzoótica porcina (NEP), una enfermedad respiratoria crónica de los cerdos de importante impacto económico. El agente, se adhiere a las células del epitelio respiratorio por medio de proteínas, llamadas adhesinas, para poder establecer la infección. Si bien se ha demostrado que la adhesión se realiza por medio de varias de estas proteínas, la adhesina P97, una proteína de 97kDa, es la más estudiada y mejor caracterizada. Por ello, se ha utilizado, entera o en fragmentos, para el desarrollo de vacunas vectorizadas en bacterias y virus, toxoides o incluso en vacunas de ADN, utilizando fragmentos del gen que la codifica. Además se ha usado para el desarrollo de algunas técnicas diagnósticas de NEP. Debido a la importancia de la enfermedad, a la necesidad de nuevas vacunas contra NEP y al conocimiento que se tiene de la adhesina P97, se presentan los hallazgos más importantes de los últimos años en el uso de la adhesina para el desarrollo de nuevas vacunas y técnicas diagnósticas.

Citas

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Publicado
2018-09-25
##submission.howToCite##
TAMIOZZO, Pablo Jesus; COTS, Agustina. Adhesina P97 de Mycoplasma hyopneumoniae. Ab Intus, [S.l.], v. 1, n. 1, p. 94-105, sep. 2018. ISSN 2618-2734. Disponible en: <http://www.ayv.unrc.edu.ar/ojs/index.php/Ab_Intus/article/view/64>. Fecha de acceso: 22 aug. 2019
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